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Gene Machine: The Race to Decipher the Secrets of the Ribosome
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Review
"It is [Ramakrishnan's] full embrace of the role of the antihero that makes Gene Machine so much fun to read and also serves as a reminder to us all of the beating human heart that lies at the center of every advance in science."―Wall Street Journal "An engaging and witty memoir... This profoundly human story is written with honesty and humility... This lucid and highly readable account will be enjoyed by students in any of the sciences, by those interested in the history of science, or who love reading memoirs. But really, I think that anyone who is captivated by an absorbing story well told will find much to appreciate in this fascinating book."―Forbes "[An] absorbing account."―Scientific American "An enchanting and invigorating work, Gene Machine casts a many-angled light on the world of science, the nature of discovery, and on one of the deepest mysteries of twentieth-century biology. Ramakrishnan, one of the key players in deciphering the molecular basis of protein translation, gives us both a rollicking scientific story and a profoundly human tale. In the tradition of The Double Helix, Gene Machine does not hesitate to highlight the process by which science advances: moving through fits and starts, often underscored by deep rivalries and contests, occasionally pitching towards error and misconception, but ultimately advancing towards profound and powerful truths. An outsider to the world of ribosome biology--an Indian immigrant, a physicist by training--Ramakrishnan retains his 'outsider's' vision throughout the text, reminding us about the corrosive nature of scientific prizes, and the intensity of competition that drives researchers (both ideas, I suspect, will have a munificent effect on our current scientific culture). Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end."―Siddhartha Mukherjee"If someone had told me that one of the most witty and enthralling books I'd read this year would be on the quest to understand ribosomes, I believe I would have laughed in his face, but I would have been quite wrong. Gene Machine is beyond superb." ―Bill Bryson"The ribosome, a structure of astonishing complexity, 'lies at the crossroads of life' and Venki Ramakrishnan played a key role in revealing its biological mysteries. His superb account lays out the science with great lucidity, but he also grants us the human face of science--the hard work and brilliant insights, of course, but also the role of luck, of personalities, jealousy, money, the roulette of major awards, and the further rewards heaped upon the fortunate. Science, in his glorious telling, becomes 'a play, with good and bad characters.' Competition and collaboration can appear inseparable, crucial figures get overlooked. It's a wonderful book and a great corrective to the notion of science as dispassionate, untainted objectivity."―Ian McEwan"The ribosome is the central processor that decodes the universal machine-code of life, and the history of its unravelling is on a par with that of DNA itself. You could think of Venki Ramakrishnan as a sort of 'nice Jim Watson.' His meticulously detailed and generous memoir has the same disarming frankness as The Double Helix. His personal honesty about the competitive ambition that drove him is tempered by his deeply thoughtful reflections on the potentially corrupting effect of big prizes. Gene Machine will be read and re-read as an important document in the history of science."―Richard Dawkins"In Gene Machine, [Ramakrishnan] thoughtfully embeds his trajectory in a wider meditation on how scientists make the decisions that lead to success or failure--and on how they struggle to solve complex problems... anyone who wants to know how modern science really works should read it. It's all here: the ambition, jealousy and factionalism--as well as the heroic late nights, crippling anxiety and disastrous mistakes--that underlie the apparently serene and objective surface represented by the published record."―Nature "Gene Machine is a must-read for anyone interested in a glimpse of the messy business of how science happens."―Times (UK)"Enlightening... one can't help celebrating with Ramakrishnan when, near his story's conclusion, the call from Stockholm arrives."―Publishers Weekly
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About the Author
Venki Ramakrishnan shared the 2009 Nobel Prize in Chemistry for uncovering the structure of the ribosome. He is a senior scientist at the MRC Laboratory of Molecular Biology in Cambridge, UK, and also the president of the Royal Society in London.
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Product details
Hardcover: 288 pages
Publisher: Basic Books; 1 edition (November 6, 2018)
Language: English
ISBN-10: 0465093361
ISBN-13: 978-0465093366
Product Dimensions:
6.4 x 1 x 9.5 inches
Shipping Weight: 1.1 pounds (View shipping rates and policies)
Average Customer Review:
4.6 out of 5 stars
26 customer reviews
Amazon Best Sellers Rank:
#38,073 in Books (See Top 100 in Books)
I have only ever read two books in one sitting; Gene Machine is one of them. As a scientist and former teacher descended from a long line of teachers, I can unreservedly say that Ramakrishnan's writing shows the traits that only the greatest teachers have: an appreciation of what the reader/student may know coming in, a talent for accessibly delivering new and complex knowledge and ideas, a broad and deep reservoir of knowledge to draw from, and a commitment to portraying how acquiring knowledge is as much a personal and societal endeavor as it is a technical exercise.Thanks to the author’s gifts, I was so drawn into the narrative that it felt as if I were experiencing the struggles and victories alongside Venki and his colleagues. Breakfast, lunch, dinner, feeding my cats, all could be ignored - there was important work to do! It made me want to go into the lab and help out, even though, as a biochemist, I knew the ending.But more than an informative, engrossing tale, Gene Machine reveals the deepest, darkest desires and fears that can bedevil the psyche of those who grapple with Mother Nature (as well as each other) to decipher her most fundamental workings. Ramakrishnan shares his feelings, and equally importantly, his feelings about those feelings, with a candor that few people, and I reckon fewer scientists, would ever risk. What shines through in these descriptions is the author's deep affection for the pursuit and a generosity of spirit for all those engaged in that pursuit, "friend" or "foe". There's a lesson in that for all of us: truly committing ourselves to that which is most enduring gives us a much more productive perspective on everything else.I highly recommend this book to anyone, scientist or not, who wants to learn more about what drives people to pursue a deep knowledge of how nature works and what we can do with that knowledge. As science leaps from the lab to our lives, cultures and economies with greater speed and impact every day, it is crucial to understand what is too often misunderstood or misrepresented in our society: the motivations and feelings of those who push themselves to the limit at the cutting edge of discovery. Some of humanity’s greatest blunders have come from failing to understand how scientific research actually works. Gene Machine is a great way to learn about it from a world-class teacher. And it is a jolly good adventure!
Most of the expert reviews of this book mention that it is a modern the successor to James Watson's "The Double Helix"; I would argue that it's a superior page-turner. The story Venki tells is more similar to a novel than nonfiction, which is credit to his skill in making the different scientists and their stories come alive.The only reason this is not a five-star review is because Venki's science writing is... not good. His attempts to explain the details of X-ray diffraction and ribosome mechanics in layman's terms fall totally flat. As a biologist who with casual familiarity with crystallography, even I was totally lost in some parts of his explanations. It turns out that Venki is no Ed Yong.However, the mechanistic details of how crystallography works are generally unimportant to this story. Venki gives a remarkable and unique view into how high-stakes science works in a day-to-day sense, with all the character flaws and triumphant efforts involved. It's a wonderful story that I would recommend to everyone I know.
This “review†is simply to offset lakedog’s. Reviews should be based on the contents of the book, not its price or ancillary matters.
The material content is good. However, the author spends a great deal of ink talking about other people he learned from and worked with. I'm supportive of this in the sense of giving credit where credit is due, but all the "name-dropping" gets in the way of reading about the science of the ribosome. In fact, the science regarding how the ribosome actually looks and works gets short shrift, in my opinion. Most of the book talks about the "how" and "who" of ribosome structural science. There's not nearly enough time spent on describing how all the parts of the ribosome are put together and how the ribosome function fits within the broader context of cellular protein manufacture. There are a few paragraphs about these issues here and there, but not nearly enough that I could walk away from the book understanding more about this intriguing and essential organelle. Compare and contrast this to the book "Life's Vital Force," which does a superlative job of describing the function, evolution and structure of the mitochondria.I want to call out the last chapter and the Epilogue as being exceptionally good. In these sections, Dr. V. Ramakrishnan does a wonderful job talking about the broader social context in which science happens, the way the Nobel Prize changed his life, and the value of science in general. He also summarizes much of the book's prior narrative and talks about new research into ribosomes, RNA and such.I would rather have seen a narrative that focuses more on describing the science, and relegates the information about collaborators etc. to footnotes or endnotes.
I don't know what I was expecting from this book, but what I got was a pretty honest portrait of the author's travels and journey throughout his career in search of the true structure of the ribosome. What I enjoyed about the book is the details included about the ribosome that were provided in greatest depth towards the end of the book, hearing about the amazing dedication of the author to solve a very specific and difficult problem in a timely manner and the author's honesty about his genuine thoughts regarding different events and even colleagues. What I did not like was the amount of name dropping of other scientists and certain conferences that didn't seem very relevant to the overall story. The style of writing is somewhat engaging, but when compared to other science books, this book is not one that I felt that I had to keep on reading because I couldn't wait to hear what happened. Instead I took my time, enjoyed parts of it and have now moved on to more interesting and engaging books. Overall, a solid read but not spectacular.
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